Sultamicillin is a Mutual Prodrug of Sulbactam & Ampicillin Sultamicillin is a semisynthetic double ester that combines ampicillin with the beta-lactamase inhibitor sulbactam To be effective against a wide range of gram(+) & gram(-) bacteria The combination of sulbactam with beta-lactam antibiotic ampicillin restores the bactericidal activity of ampicillin Enables a convenient bid dosing